Do You Need a Business License to Sell Online in Missouri? Requirements to Start an E-commerce Business in Missouri

  • You will need a business license from the Secretary of State office in Jefferson City, Missouri to start an e-commerce business.
  • You will need to charge sales tax on sales in Missouri if you have a physical presence within the state.
  • You can register for a sales tax permit online through the Missouri Department of Revenue website.
  • Missouri law requires that all businesses selling goods and services within the state obtain a sales tax license to charge sales tax.
  • Some cities require home-based businesses to get a business operating permit before legally operating.
  • If your business involves selling goods or services subject to sales tax in Missouri, you will need to obtain a sales tax permit from the Missouri Department of Revenue.
  • There is no statewide general license, but state, professional, and local licenses and permits may be required depending on your business type and location.
  • You can apply online or in person at your local clerk’s office with fees varying by business type and location.
  • Research licensing requirements and register on the Division of Professional Registration website.

The Missouri Division of Professional Registration has a Listing of Professions you should review to help you determine if your Missouri business needs an occupational license or permit. Alternatively, review the Division of Professional Registration’s Listing of Boards to see if your industry or occupation needs a business license in Missouri.


You may require licenses and permits at state, city, and county levels in Missouri. Each city has rules that make licensing complex, so it is advisable to contact local governments to find specific requirements.

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